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[TEXWILLER72]

Microplasmin injection may offer a nonsurgical treatment option

Intravitreal injection of microplasmin may be effective as a nonsurgical treatment for vitreomacular traction, according to results of the phase 2 MIVI-2T trial.

“Microplasmin is able to nonsurgically induce traction release in 40% [of patients] and macular hole closure in half of the patients,” Peter Stalmans, MD, PhD, said.

At three centers in Belgium, Dr. Stalmans and colleagues investigated the ability of a single intravitreal microplasmin injection to induce posterior vitreous detachment and nonsurgically relieve vitreomacular traction in 30 patients. Of these patients, 12 were randomly assigned to treatment with a 75-µg microplasmin injection, 12 were assigned to treatment with a 125-µg injection and six received a sham injection.

Four microplasmin-treated patients and two control patients had macular holes.

Posterior vitreous detachment was induced in four microplasmin-treated patients and in none of the control patients. Also, vitreomacular traction resolved in nine microplasmin-treated patients and two control patients, Dr. Stalmans said.

In addition, two macular holes in patients treated with microplasmin were closed, but neither of the two macular holes seen in control patients had closed.

In terms of vision, four microplasmin-injected patients had at least a three line improvement, while there was no improvement in vision among control patients.

“Regarding the safety, we found that the study drug was well-tolerated,” Dr. Stalmans said.


Tratto da : http://www.osnsupersite.com/view.aspx?rid=25647
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T E X = [Moderatore]

[TEXWILLER72]

Un altro link sull'argomento:

http://www.retinatoday.com/issues/0108/0108_08.pdf
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T E X = [Moderatore]

[bitchou1]

Ciao,
Giusto per tenervi ragazzi in trasferta, si sa qualcosa di più sul prossimo esperimento del dottor Stalmans.
Ho accennato in tema Crevatin che un membro del forum speaking English (Yuku) è stato detto dal Dr Stalmans about uno esperimento possibile, che consisterebbe nel dare ai pazienti prima gocce they sottoposti vitrectomia nella speranza che floater scomparire.

Beh, abbiamo qualche notizia di più. Non sarà un collirio, ma l'iniezione nel vitreo. Si può sapere di più se il comitato etico autorizza l'esperimento il Mercoledì.

Perché questo medico ha lavorato su microplasmin per lungo tempo, si può supporre che egli provare questo prodotto per floater.



Hi,
Just to keep you guys posted, we know a little more about Dr Stalmans's upcoming experiment.
I mentioned in Crevatin's topic that a member of the English speaking forum (Yuku) was told by Dr Stalmans about a possible experiment which would consist in giving drops to patients before they undergo vitrectomy in the hope that floaters disappear.

Well we have some more news. It won't be eye drops but an injection in the vitreous. We may know more if the ethics committee authorizes the experiment on Wednesday.

Because this doctor has been working on microplasmin for a long time, we may assume that he will try this product for floaters.

[Davide]

Many Thank for that update bitchou1, this new sound very interesting.

Seem that will be the first microplasmin application for floater....wow !

Keep us informed about that if you have news.

Thanks

/Davide

[robemuna]

[bitchou1]

Ciao robemuna,

Purtroppo non ci sono notizie per il momento. Stalmans Dottore ci terrà postato qualcosa di nuovo quando viene in su.


Hi robemuna,

Unfortunately there are no news for the moment. Doctor Stalmans will keep us posted when something new comes up.

[FloatEire]

(english/italian traduzione) Buone notizie a tutti! Ora speriamo di sapere se in entrambi i casi microplasmin ha alcun effetto.

http://oneclearvision.org/node/90

degli studi clinici in microplasmin nel trattamento di floaters dell'occhio

Stalmans Professore dell'Azienda Ospedaliero-Universitaria, Lovanio, ha confermato a noi che ha recentemente ricevuto l'autorizzazione a condurre uno studio clinico di iniettare un numero limitato di pazienti floater prevista per vitrectomia con microplasmin prima della chirurgia. Questo gli permetterà di determinare se microplasmin può essere utile nel trattamento di corpi mobili vitreali.

Plasmina è un enzima nel sangue responsabile per la dissoluzione proteine del plasma sanguigno, in particolare, coaguli di fibrina. Microplasmin è una forma troncata e stabile di questo enzima.

Riferimenti:

* Gandorfer Arnd, Rohleder Matthias, Sethi Charanjit, Dominik Eckle,
Ulrich Welge-Lu ¨ ssen, Anselm Kampik, Philip Luthert, 3 e David Charteris. Distacco del vitreo posteriore Indotto da Microplasmin. http://www.iovs.org/cgi/reprint/45/2/641
* Pipeline Microplasmin ThromboGenics. http://www.thrombogenics.com/html/pipeline2.asp accedere Giugno, 2010

[robemuna]

Ottimo! incrociamo le dita adesso e speriamo bene.

[vitto78]

Notizia storica!!

[anonimo]

quindi approsimativamente quando sarà possibile il suo utlizzo..?

[emarcbo]

Ciao

Maurizio D'Amelio sta seguendo attentamente la vicenda.



Bye
Marco da Genova

[emarcbo]

Ciao a tutti


Beh e come non potvo contatare Pter Stalmans personamente.
Purtoppo questa e' la risposta.



==============================================
Peter Stalmans a me
mostra dettagli 21:34 (11 ore fa)



Dear sir,

We are presently testing microplasmin only in conjunction with vitrectomy in a limited number of patients, not as a sole treatment.

Sincerely,

P. Stalmans

==============================================

Bye
Marco da Genova

[alvind]

Ciao Marco

Any preliminary results from the Stalmans study?

Alvind

[emarcbo]

[alvind]

Marco

I think he says that because things may go bad with the microplasmin and he wants to be looking at a vitrectomy surgery anyways. But in my opinion this does not mean that microplasmin alone cannot reduce the floater symptoms. I think this study will also investigate this. If they find out that certain doses of microplasmin reduces floaters but does not cause the vitreous to collapse, then that may be useful for floaters.